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Clinical equipoise requires honest, professional disagreement as to the preferred treatment: standard of care (monotherapy) versus new treatment (combination therapy) at dosages that are chosen based upon strong preliminary “proof-of-concept” data, and using doses and formulations that would not be contested by its proponents ().
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Thyroid replacement therapy and its influence on postheparin plasma lipases and apolipoprotein-B metabolism in hypothyroidism.
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